Pure Retinol in Luxurious Plant Oils 0.5%

Description
The most researched non-prescription Vitamin A derivative in a lightweight,
fast penetrating, sensorially luxurious oil format. Stabilised with
Lipochroman and Vitamin E. Boosted with Tetrahydropiperine. Soothed with
Defensil Plus and calming extracts of Chamomile and Calendula.

Formulated to help rejuvenate the appearance of the skin and give an overall improvement to skin texture.

Manufactured / packaged under nitrogen, into airless containers.

As we age our skin experiences a number of physiological changes such
as thinning of the dermis and epidermis as well as a reduction in
keratinocytes and collagen production. In addition to natural ageing,
the skin is repeatedly exposed to environmental stressors such as UV
radiation, pollution etc. Thinning of the dermis and epidermis results
in a less effective skin barrier function and in turn leads to higher
environmental stressors, higher trans-epidermal water loss and
vulnerable skin.

Retinol exhibits powerful anti aging action by increasing the production
of keratinocytes (cells which produce keratin), endothelial cells
(increases dermal vascularity) and fibroblasts (synthesizes collagen and
extracellular matrix).

This in turn leads to:
– Thickening of the epidermis
– Stimulation of collagen production
– Increase in skin firmness
– Increase in cellular renewal
– Decrease in fine lines and wrinkles

Retinol has shown to inhibit UV induced Matrix Metalloproteinases
(enzymes which degrade collagen and prevent new collagen production).

Regulate oil production and reduce acne/blemishes.

Reduce collagenase.

Brightens skin tone.

Evens out skin tone.

Increases wound healing.

Considerably less erythema, irritation, TEWL, compared to tretinoin / retinoid acid.

Retinol boosts the effects of hydroxy acid peels due to increased
cellular renewal, increased epidermal healing and enhanced penetration
of the peeling agent. Retinol can be resumed after all evidence of
peeling and irritation subsides.

References:
• J Invest Dermatol. 1995;105:549–56.
• Skin Res Technol. 1998 Nov;4(4):237-43.
• Nature. 1996 Jan 25;379(6563):335-9.
• N Engl J Med. 1997 Nov 13;337(20):1419-28.
• Journal of Cosmet Dermatol. 15, 49-57
• Clin Cosmet Investig Dermatol. 2015 Aug 26;8:455-61.
• Arch Dermatol. 2007;143(5)606-12
• Int J Cosmet Sci. 2017 Feb 39(1)56-65
• J Invest Dermatol. 1996 Aug;107(2):178-82.
• Skin Res Technol. 1998 Nov;4(4):237-43.
• J Invest Dermatol. 2000 Mar;114(3):480-6.

Warning – May cause irritation. Skin may also start to shed dead skin cells within the first week and may last a further week.

Avoid direct and unprotected exposure to sun.
DO NOT use during pregnancy.
DO NOT use on sensitive skin conditions.
 
Directions:

Introduce this serum into a skincare regime gradually.
Apply in the evening over serums and under face creams.
Keep skin moisturised with hydrating serums or face cream after use.
 
Ingredients:

Squalane (Plant derived), Simmondsia
Chinensis (Jojoba) Oil (Organic), C13-15 Alkane (Hemi Squalane), Vitis
Vinifera (Grape Seed) Oil,Caprylyl Caprylate/Caprate, Caprylic/Capric
Triglyceride, Chamomilla Recutita (Chamomile) Extract (Organic),
Calendula Officinalis (Calendula) Extract (Organic), Tocopheryl Acetate
(Vitamin E), Octyldodecanol, Ribes Nigrum (Black Currant) Seed Oil,
Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables, Cardiospermum
Halicacabum Flower/ Leaf/Vine Extract, Tocopherol, Helianthus Annuus
(Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract,
Retinol (0.5%), Tetrahydropiperine, Dimethylmethoxy Chromanol.

La
Clinica For Skin and Body prides itself on its innovation and thus the
ingredients listed here may differ from the packaging depending on the
time and region of purchase.


Squalane (plant derived) 


A
powerful emollient with high oxidative stability found and created
naturally in our skin. Squalane has occlusive properties yet is
non-comedogenic and assists dry, inflamed skin conditions. It supports
the skin’s barrier and has anti-bacterial properties. 



 Simmondsia Chinensis (Jojoba) Oil (Organic)
Jojoba
Oil is very similar to the sebum created by the sebaceous glands within
the dermis. Sebum is fundamental for skin health. It assists in keeping
the skin moisturised, maintains skin elasticity and preserves the
skin’s barrier. Due to Jojoba oil’s sebum like qualities it is readily
accepted and easily absorbed by our skin and has shown to be effective
in enhancing the permeation and efficacy of the active ingredients it is
combined with.
G Ital Dermatol Venereol. 2013 Dec;148(6):687-91
Curr Drug Deliv. 2017;14(3):426-432 

Jojoba
oil exhibits high oxidative stability and resistant to premature
degradation. Studies suggest Jojoba oil accelerates wound healing and
stimulates collages synthesis.
J Ethnopharmacol. 2011 Mar 24;134(2):443-9.

C13-15 Alkane (Hemi Squalane)
A lightweight, ultra fast absorbing emollient derived from sugar.

Chamomilla Recutita (Chamomile) Extract (Organic)
Chamomile
extract has strong anti-inflammatory effects on the skin. It inhibits
nitric oxide production within the dermis. Nitric oxide is a catalyst
for inflammatory diseases and is associated with acute and chronic
inflammations. Chamomile extract has anti-oxidant and antimicrobial
properties and has shown to enhance wound healing.
Electron Physician. 2016 Sep; 8(9): 3024–3031.
Int J Mol Med. 2010 Dec; 26(6): 935–940.

Wound healing (in-vivo)
Z Hautkr. 1987 Sep 1;62(17):1262, 1267-71.
J Wound Care. 2007 Jul;16(7):298-302.

Calendula Officinalis (Calendula) Extract (Organic)
Strong anti inflammatory action.
Indian J Exp Biol. 2009 Feb;47(2):113-20.

Wound healing (in-vivo)
J Wound Care. 2016 Dec 2;25(12):732-739.

Has shown to enhance collagen (in-vivo) and inhibit the activity of collagenase (in-vitro).
J Ethnopharmacol. 2017 Jan 20;196:94-103.

Has demonstrated protection against oxidative stress.
Phytother Res. 2015 Jan;29(1):120-4. 

Has shown to ameliorated the oxidant effects of cigarette smoke.
Toxicology and Industrial Health 2011 April 28(1):3-9

Tocopheryl Acetate (Vitamin E)
Anti-oxidant. Assists the stability of the natural oils and Retinol

Defensil Plus [Octyldodecanol,
Ribes Nigrum (Black Currant) Seed Oil, Helianthus Annuus (Sunflower)
Seed Oil Unsaponifiables, Cardiospermum Halicacabum Flower/ Leaf/Vine
Extract, Tocopherol, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus
Officinalis (Rosemary) Leaf Extract.]

A
combination of Blackcurrant Seed Oil, Sunflower Oil and Ballon Vine
Extract; To ease inflammation and support the recovery of the skin
barrier (Group 2 & 3). Ballon vine extract a plant-derived
alternative to hydrocortisone, soothes the skin.

• Protects and regenerates the damaged skin barrier (in-vivo study)

• Nips inflammatory processes in the bud (in-vitro study)

• Reduces allergic reaction (in-vitro study)

• Reduces tissue damage resulting from mosquito bites (in-vivo study)

• Soothes the skin after shaving and epilation (in-vivo study)

• Reduces the severity of couperose (in-vivo study)

Retinol (0.5%)

Cosmoperine [Tetrahydropiperine]
A patented natural permeation enhancer to increase the absorption and efficacy of actives in topical applications.

Dimethylmethoxy Chromanol
Also known as Lipochroman.

A
potent anti oxidant that boosts the skin’s ability to resist oxidative
damage due to external stressors and promotes the body’s natural detox
process.

Demonstrated
higher anti-oxidative power than well known anti-oxidants such as
Ascorbic Acid (Vitamin C), Vitamin E and Coenzyme Q10. (Click here)

Provided potent singlet oxygen (ROS) scavenging activity.



Boosted the expression of key players in the detoxification of
environmental stressors and ROS. Helped boost skin’s ability to resist
oxidative damage and enhance its elasticity, while also improving the
appearance of aging signs (wrinkles and dark spots)

In this application it may assist the protection of retinol and natural oils from premature oxidation.